| Date | May 7 | Total matches | 5 |
| Men's matches | 3 | Women's matches | 1 |
| Singles matches | 4 | Tag Team matches | 0 |
This episode of SmackDown took place on May 7, 2021 and featured 5 matches on the card. A majority of the matches ended by pinfall, submission, or the rules stipulated by the match, but 1 of the 5 matches ended with a non-finish disqualification or count-out. No championships were defended on the card.
The matches featured 18 wrestlers, highlighted by Apollo Crews, Sami Zayn, Baron Corbin, Chad Gable, Otis, Tamina, Dominik Mysterio and Carmella.
| Men's Five on Five Tag Team |
| Singles |
3-1 (Overall: 7-3, Last 5: 4-1) |
| Match ended by Disqualification |
| Men's Singles |
3-2 (Overall: 7-7, Last 5: 2-3) |
0-3 (Overall: 5-6, Last 5: 3-2) |
| Women's Singles |
1-2 (Overall: 2-3, Last 5: 2-3) |
0-2 (Overall: 1-5, Last 5: 0-5) |
| Men's Singles |
8-1 (Overall: 11-5, Last 5: 5-0) |
2-2 (Overall: 2-3, Last 5: 2-3) |