| Date | Apr 23 | Total matches | 2 |
| Men's matches | 2 | Women's matches | 0 |
| Singles matches | 1 | Tag Team matches | 0 |
This episode of Ring of Honor 501 took place on April 23, 2021 and featured 2 matches on the card. A majority of the matches ended by pinfall, submission, or the rules stipulated by the match, but 2 matches had no clear winner. No championships were defended on the card.
The matches featured 8 wrestlers, highlighted by La Bestia Del Ring, Rush, Kenny King, Brody King, Chris Dickinson, Homicide, Dak Draper and Eli Isom.
| Men's Three on Three Tag Team |
| Match ended in a No Contest |
| Men's Singles |
1-1-1 (Overall: 1-1-1, Last 5: 1-1-1) |
2-1-1 (Overall: 2-1-1, Last 5: 2-1-1) |
| Match ended in a No Contest |