| Date | Apr 16 | Total matches | 3 |
| Men's matches | 3 | Women's matches | 0 |
| Singles matches | 3 | Tag Team matches | 0 |
This episode of Ring of Honor 500 took place on April 16, 2021 and featured 2 matches on the card. A majority of the matches ended by pinfall, submission, or the rules stipulated by the match, but 1 of the 3 matches ended with a non-finish disqualification or count-out. Only one championship, the Pure Championship, was defended on the card.
The matches featured 6 wrestlers, highlighted by Jonathan Gresham, Mark Briscoe, The Beer City Bruiser and Jay Lethal.
| Men's Singles |
1-1 (Overall: 1-2-1, Last 5: 1-2-1) |
1-2 (Overall: 1-3-1, Last 5: 1-3-1) |
| Match ended by Count-out |
| Men's Singles Pure Championship |
3-0 (Overall: 4-4, Last 5: 3-2) Champion |
1-3 (Overall: 3-6, Last 5: 2-3) |
| Men's Singles |
1-0-1 (Overall: 1-1-1, Last 5: 1-1-1) |
0-2 (Overall: 0-2, Last 5: 0-2) |