| Date | Mar 13 | Total matches | 9 |
| Men's matches | 6 | Women's matches | 3 |
| Singles matches | 4 | Tag Team matches | 5 |
Sacrifice took place on March 13, 2021 and featured 9 matches on the card. All of the matches ended by pinfall, submission, or the rules stipulated by the match. Multiple championships were defended on the card, including the World, Tag Team, Knockouts, X-Division and Knockouts Tag Team Championships.
The matches featured 28 wrestlers and 10 tag teams, highlighted by Rich Swann, Kiera Hogan, Tasha Steelz, Deonna Purrazzo and T.J. Perkins.
| Men's Singles World Championship |
3-0 (Overall: 4-2, Last 5: 3-2) Champion |
3-3 (Overall: 4-5, Last 5: 3-2) |
| Men's Tag Team Tag Team Championship |
2-0 (Last 5: 2-0) |
2-2 (Last 5: 2-2) Champions |
| Women's Singles Knockouts Championship |
3-0 (Overall: 3-1, Last 5: 3-1) Champion |
1-2 (Overall: 2-2, Last 5: 2-2) |
| Men's Singles X-Division Championship |
5-4 (Overall: 6-6, Last 5: 3-2) |
3-2 (Overall: 3-2, Last 5: 3-2) Champion |
| Women's Tag Team Knockouts Tag Team Championship |
3-0 (Last 5: 3-0) Champions |
1-3 (Last 5: 1-3) |
| Men's Singles |
4-1-1 (Overall: 4-2-1, Last 5: 3-2) |
3-2 (Overall: 4-2, Last 5: 3-2) |
| Men's Tag Team |
1-0 (Last 5: 1-0) |
2-3 (Last 5: 2-3) |
| Women's Tag Team |
1-0 (Last 5: 1-0) |
1-3 (Last 5: 1-3) |
| Men's Tag Team |
2-0 (Last 5: 2-0) |
0-2 (Last 5: 0-2) |